In a word-processing document

Ctrl + Mouse Scroll Wheel
Zoom in or out. It changes the % in the zoom drop down menu.

Ctrl + C
Copy. Places the selected/highlighted copy on the clipboard.

Ctrl + X
Cut. Removes the selected/highlighted copy and places it on the clipboard.

Ctrl + V
Paste. Inserts the copy on the clipboard into the area where your flashing cursor is positioned or the area you have selected/highlighted.

Ctrl + Z
Undo last command.

Ctrl + Y
Redo last command.

Ctrl + O
Open. Brings up a browse dialog and allows you to select a file to open.

Ctrl + P
Brings up the Print window.

Ctrl + N
Creates a new blank document.

Ctrl + A
Selects all the text and items in the page.

Ctrl + S
Saves the file.

Ctrl + F
Brings up the Find and Replace window.

Ctrl + B
Makes your text bold.

Ctrl + I
Makes your text italic.

Ctrl + U
Makes the text underlined.

Using Internet Explorer

Ctrl + F
Displays a Find on the page dialog box and allows you to search content on the page you are viewing in your browser. This is a nice feature if you are searching for a specific reference on the page.

Ctrl + N
Opens a new window in Internet Explorer.

Ctrl + W
Closes the currently open Internet Explorer window.

Backspace
Go Back to the previous page.

Shift + Click
While clicking on a hyperlink on a web page, opens that link in a new browser window.

Space Bar
Scroll Downward.

Space Bar + Shift
Scroll Upward. You can also use the Page Down or Page Up keys.

End
Go to End of page.

Home
Go to Top of page.

In combination with the Start key

Start key + E
Opens an instance of Windows Explorer, centered on "My Computer."

Start key + F
Opens the "Find Files or Folders" dialog box.

Start key + Ctrl + F
Opens the "Find Computer" dialog box.

Start key + M
Minimizes all open windows.

Start key + Shift + M
Undo the "minimize all" function (re-open all current windows).

Start key + R
Opens the "Run" dialog box.

Start key + Pause
Opens the system properties panel.